Trifluoroacetic acid → HCID 131714605, compound

HRID 246921Notes

Reaction equation

HRID 246921 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:8]([NH:10][C@H:11]([C:16]([NH:18][C@H:19]([C:22]([NH:24][C@H:25]([C:27]([O:29][CH3:30])=[O:28])[CH3:26])=[O:23])[CH2:20][OH:21])=[O:17])[CH2:12][CH:13]([CH3:15])[CH3:14])=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[NH2:6].C(O)(C(F)(F)F)=O>ClCCl>[NH2:1][C@H:2]([C:8]([NH:10][C@H:11]([C:16]([NH:18][C@H:19]([C:22]([NH:24][C@H:25]([C:27]([O:29][CH3:30])=[O:28])[CH3:26])=[O:23])[CH2:20][OH:21])=[O:17])[CH2:12][CH:13]([CH3:15])[CH3:14])=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[NH2:6]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 131714606HCID 131714606, compound

Product 1

HCID 131714605HCID 131714605, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

10.3 g (18.8 mM) of Boc-Gln-Leu-Ser-Ala-OCH3 are stirred for 35 mins. in 100 ml of dichloromethane containing 100 ml of TFA. The reaction medium is concentrated in vacuo to about 50 ml and poured over 300 ml of ether. The precipitate is drained, washed with ether and dried in vacuo.

Workup

  1. concentrationThe reaction medium is concentrated in vacuo to about 50 ml
  2. additionpoured over 300 ml of ether
  3. washwashed with ether
  4. customdried in vacuo

Sources & evidence

ORD record
ord-69d8d7e2398f4819947482d8fed297c8
Source dataset
uspto-grants-1987_11
Patent number
US04704450

Reaction notes

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