2,6-Dimethylmorpholine, cis- → HCID 13577276, compound

HRID 246988Notes

Reaction equation

HRID 246988 reaction equation
[CH3:1][CH:2]([CH2:5][CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH2:3]Cl.[CH3:14][C@H:15]1[O:20][C@@H:19]([CH3:21])[CH2:18][NH:17][CH2:16]1>C(Cl)Cl>[CH3:1][CH:2]([CH2:5][CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH2:3][N:17]1[CH2:16][C@H:15]([CH3:14])[O:20][C@H:19]([CH3:21])[CH2:18]1

Participants

4

Reactant 2

HCID 6415002,6-Dimethylmorpholine, cis-HCID 13577269HCID 13577269, compound

Product 1

HCID 13577276HCID 13577276, compoundYield 64.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

20 g of 2-methyl-5-phenylpentyl chloride and 35 g of 2,6-cis-dimethylmorpholine are heated at 150° C. for 10 hours, after which the mixture is left to cool, taken up with CH2Cl2, washed with water, dilute NaOH and once again with water, dried over Na2SO4 and evaporated down, and the residue is distilled to give 18 g of a product of boiling point 130°-132° C./0.4 mbar.

Workup

  1. waitafter which the mixture is left
  2. temperatureto cool
  3. washwashed with water, dilute NaOH and once again with water
  4. dry with materialdried over Na2SO4
  5. customevaporated down
  6. distillationthe residue is distilled

Sources & evidence

ORD record
ord-3af62c1d30624527b1c29a3cb8b6e6a4
Source dataset
uspto-grants-1987_11
Patent number
US04705553

Reaction notes

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