Ethanethiol → HCID 88638091, compound

HRID 247035Notes

Reaction equation

HRID 247035 reaction equation
FC(F)(F)C(O)=O.C(S)C.C([O:30]/[N:31]=[C:32](/[C:53]1[N:54]=[CH:55][S:56][CH:57]=1)\[C:33]([NH:35][CH:36]1[C:51](=[O:52])[N:38]2[C:39]([C:48]([OH:50])=[O:49])=[C:40]([CH2:43][O:44][C:45](=[O:47])[NH2:46])[CH2:41][S:42][C@H:37]12)=[O:34])(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>>[OH:30]/[N:31]=[C:32](/[C:53]1[N:54]=[CH:55][S:56][CH:57]=1)\[C:33]([NH:35][CH:36]1[C:51](=[O:52])[N:38]2[C:39]([C:48]([OH:50])=[O:49])=[C:40]([CH2:43][O:44][C:45](=[O:47])[NH2:46])[CH2:41][S:42][C@H:37]12)=[O:34]

Participants

4

Reactant 3

HCID 6343EthanethiolHCID 6422Trifluoroacetic acidHCID 88637907HCID 88637907, compound

Product 1

HCID 88638091HCID 88638091, compoundYield 78.3%

Procedure

To a stirring mixture of trifluoroacetic acid (3 ml) and ethyl mercaptan (1 ml) was added 7-[(Z)-2-trityloxyimino-2-(thiazol-4-yl)acetamido]-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid (110 mg). The stirring was continued for 110 min at room temperature. The reaction mixture was concentrated to dryness under reduced pressure at room temperature. Resulting crystals were washed with diethyl ether, and dried in vacuo over calcium chloride to give the title compound (55 mg).

Workup

  1. concentrationThe reaction mixture was concentrated to dryness under reduced pressure at room temperature
  2. customResulting crystals
  3. washwere washed with diethyl ether
  4. dry with materialdried in vacuo over calcium chloride

Sources & evidence

ORD record
ord-8ffe21c528024ca48f1b5b3f9f0f24a0
Source dataset
uspto-grants-1987_11
Patent number
US04705784

Reaction notes

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