4-Chlorobutyronitrile → HCID 15589479, compound

HRID 247047Notes

Reaction equation

HRID 247047 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][NH:4][CH2:3]1.Cl[CH2:9][CH2:10][CH2:11][C:12]#[N:13]>C1C=CC=CC=1>[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][N:4]([CH2:9][CH2:10][CH2:11][C:12]#[N:13])[CH2:3]1

Participants

4

Reactant 2

HCID 123364-ChlorobutyronitrileHCID 790813-Methylpiperidine

Product 1

HCID 15589479HCID 15589479, compoundYield 70.3%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

In a solution under reflux of 58.6 ml (0.50 mole) of 3-methylpiperidine in 65 ml of benzene, were run in 25 minutes 27.2 g (0.25 mole) of 4-chlorobutyronitrile Reflux was continued for 2h, the precipitate was removed by filtration and the filtrate brought to dryness under reduced pressure. The residue from the evaporation was purified by distillation under reduced pressure to give 29.2 g (yields=70.3%) of 4-(3-methylpiperidino)-butyronitrile which was in the form of a colourless oil. Boiling point 5-6 mmHg =100° C.

Workup

  1. customthe precipitate was removed by filtration
  2. customThe residue from the evaporation
  3. distillationwas purified by distillation under reduced pressure

Sources & evidence

ORD record
ord-021c11c3d6314ad7a33c8d03d85e1b1e
Source dataset
uspto-grants-1987_11
Patent number
US04705795

Reaction notes

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