Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Nitrobenzaldehyde → Methyl 1,4-dihydro-2,6-dimethyl-3-(3-chloromethyl-1,2,4-oxadiazol-5-yl)-4-(3-nitrophenyl)pyridine-5-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Nitrobenzaldehyde | HCID 7449 | — |
| 반응물 | Methyl 3-aminocrotonate | HCID 643918 | — |
| 반응물 | 5-Acetonyl-3-chloromethyl-1,2,4-oxadiazole | HCID 13824705 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | Methyl 1,4-dihydro-2,6-dimethyl-3-(3-chloromethyl-1,2,4-oxadiazol-5-yl)-4-(3-nitrophenyl)pyridine-5-carboxylate | HCID 135833416 | 63.7% |
반응 단계
A solution of 8.0 g of 5-acetonyl-3-chloromethyl-1,2,4-oxadiazole, 6.92 g of 3-nitrobenzaldehyde and 5.27 g of methyl 3-aminocrotonate in 20 ml of isopropyl alcohol was heated under reflux for 6 hours. After ice-cooling, the precipitated solid was collected by filtration, washed with cold isopropyl alcohol and dried to give 11.8 g of methyl 1,4-dihydro-2,6-dimethyl-3-(3-chloromethyl-1,2,4-oxadiazol-5-yl)-4-(3-nitrophenyl)pyridine-5-carboxylate as yellow crystals, m.p. 200.5°-201.5° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04705786 |
| 출처 데이터셋 | uspto-grants-1987_11 |
| ORD ID | ord-9cb3060ce6c548bf914909ad65d20b68 |
| 출처 메모 | uspto-grants-1987_11 |