反应详情

A stirred solution of 1.0 g of 5-acetonyl-3-chloromethyl-1,2,4-oxadiazole, 0.95 g of 3-nitrobenzaldehyde and 0.52 g of 3-aminocrotononitrile in 10 ml of isopropyl alcohol was heated under reflux for 4 hours and then concentrated in vacuo. The residue was chromatographed on silica gel using chloroform-methanol (40:1) as eluent to give 0.90 g of 1,4-dihydro-2,6-dimethyl-3-(3-chloromethyl-1,2,4-oxadiazol-5-yl)-4-(3-nitrophenyl)pyridine-5-carbonitrile, m.p. 204.5°-206.5° C.

1. temperatureunder reflux for 4 hours
2. concentrationconcentrated in vacuo
3. customThe residue was chromatographed on silica gel