化工社化工社 化学情報印刷レポート · 研究参考用
3-Nitrobenzaldehyde → 1,4-Dihydro-2,6-dimethyl-3-(3-chloromethyl-1,2,4-oxadiazol-5-yl)-4-(3-nitrophenyl)pyridine-5-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Nitrobenzaldehyde | HCID 7449 | — |
| 反応物 | (2Z)-3-Amino-2-butenenitrile | HCID 5325263 | — |
| 反応物 | 5-Acetonyl-3-chloromethyl-1,2,4-oxadiazole | HCID 13824705 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 1,4-Dihydro-2,6-dimethyl-3-(3-chloromethyl-1,2,4-oxadiazol-5-yl)-4-(3-nitrophenyl)pyridine-5-carbonitrile | HCID 135833443 | 42.3% |
反応手順
A stirred solution of 1.0 g of 5-acetonyl-3-chloromethyl-1,2,4-oxadiazole, 0.95 g of 3-nitrobenzaldehyde and 0.52 g of 3-aminocrotononitrile in 10 ml of isopropyl alcohol was heated under reflux for 4 hours and then concentrated in vacuo. The residue was chromatographed on silica gel using chloroform-methanol (40:1) as eluent to give 0.90 g of 1,4-dihydro-2,6-dimethyl-3-(3-chloromethyl-1,2,4-oxadiazol-5-yl)-4-(3-nitrophenyl)pyridine-5-carbonitrile, m.p. 204.5°-206.5° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04705786 |
| 出典データセット | uspto-grants-1987_11 |
| ORD ID | ord-c15cf5165f0e472a8c9fc168441ad460 |
| 出典メモ | uspto-grants-1987_11 |