反应详情

450 mg (1.5 mmol) of 1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-2-indolinone and 0.41 ml of (4.5 mmol) of aniline are stirred in 7 ml of DMF for 90 minutes at 120° C. After cooling to ambient temperature 7 ml of methanol and 3 ml of 1N sodium hydroxide solution are added. The mixture is stirred for 20 minutes, then diluted with water, the crystalline reaction product is suction filtered and dried.

1. additionare added
2. filtrationfiltered
3. customdried