Hydrochloric Acid → HCID 178517079, compound

HRID 24735Notes

Reaction equation

HRID 24735 reaction equation
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[NH:11]/[C:12](=[C:19]1\[C:20](=[O:28])[NH:21][C:22]2[C:27]\1=[CH:26][CH:25]=[CH:24][CH:23]=2)/[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:4].O1CCOCC1.[OH-].[Na+].Cl>CO>[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[NH:11]/[C:12](=[C:19]1\[C:20](=[O:28])[NH:21][C:22]2[C:27]\1=[CH:26][CH:25]=[CH:24][CH:23]=2)/[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)([OH:4])=[O:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 312751,4-DioxaneHCID 178497641HCID 178497641, compound

Product 1

HCID 178517079HCID 178517079, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
80 °C

Procedure

176 mg (0.48 mmol) of (Z)-3-[1-(2-methoxycarbonyl-phenylamino)-1-phenyl-methylidene]-2-indolinone are dissolved in 15 ml of methanol and 2 ml of dioxane and after the addition of 1.4 ml of 1N sodium hydroxide solution stirred for two hours at 80° C. Then the mixture is neutralised 1.4 ml of 1N hydrochloric acid while being cooled, the product precipitated is suction filtered, washed with water and dried.

Workup

  1. temperaturewhile being cooled
  2. customthe product precipitated
  3. filtrationfiltered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-e7104c5d4f784f35b482b447e3f33f95
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

Loading…