Formic Acid → 3,5-Difluoro-4-methoxybenzaldehyde

HRID 247421Notes

Reaction equation

HRID 247421 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:12])[C:9]=1[O:10][CH3:11])[C:5]#N.C(O)=[O:14]>>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:12])[C:9]=1[O:10][CH3:11])[CH:5]=[O:14]

Participants

3

Reactant 2

HCID 284Formic AcidHCID 105832533,5-Difluoro-4-methoxybenzonitrile

Product 1

HCID 144508603,5-Difluoro-4-methoxybenzaldehyde

Procedure

3,5-Difluoro-4-methoxybenzonitrile (0.237 mol), Raney alloy (40 g) and 90% formic acid (400 ml) were reacted substantially as described in Example 7A above to obtain 22.9 g (56%) of a white, low melting solid.

Workup

  1. customto obtain 22.9 g (56%) of a white, low melting solid

Sources & evidence

ORD record
ord-e47acd577b1744ea8d641753afdbd575
Source dataset
uspto-grants-1987_11
Patent number
US04707488

Reaction notes

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