Methylamine → Hydrochloric Acid

Participants

Reaction Steps

Following the general procedure of Example 2, 3-acetyl-7-chlorosulfonyl-8-methoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine is treated with methylamine and then with refluxing hydrochloric acid to give 8-methoxy-7-(N-methylsulfamoyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride. By the procedure of Example 2, the methoxy compound is treated with hydrobromic acid to afford 8-hydroxy-7 (N-methylsulfamoyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide.

Provenance & Evidence