Dimethylamine → Hydrochloric Acid

HRID 247444Notes

Reaction equation

HRID 247444 reaction equation
C([N:4]1[CH2:10][CH:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8]2[CH:17]=[C:18]([O:25][CH3:26])[C:19]([S:21]([Cl:24])(=[O:23])=[O:22])=[CH:20][C:7]=2[CH2:6][CH2:5]1)(=O)C.[CH3:27][NH:28][CH3:29]>>[ClH:24].[ClH:24].[CH3:26][O:25][C:18]1[C:19]([S:21](=[O:22])(=[O:23])[N:28]([CH3:29])[CH3:27])=[CH:20][C:7]2[CH2:6][CH2:5][NH:4][CH2:10][CH:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:8]=2[CH:17]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 20160682HCID 20160682, compound

Product 2

HCID 313Hydrochloric AcidHCID 20160736HCID 20160736, compound

Procedure

3-Acetyl-7-chlorosulfonyl-8-methoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine is treated with dimethylamine and then with refluxing hydrochloric acid to give 8-methoxy-7-(N,N-dimethylsulfamoyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride.

Sources & evidence

ORD record
ord-179d3cb510ef4b86b5e2db82bb67fa9d
Source dataset
uspto-grants-1987_11
Patent number
US04707483

Reaction notes

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