Thionyl Chloride → HCID 20160730, compound

HRID 247445Notes

Reaction equation

HRID 247445 reaction equation
[C:1]([OH:8])(=O)/[CH:2]=C\C(O)=O.[CH3:9][O:10][C:11]1[CH:27]=[CH:26][C:14]2[CH:15]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:16][NH:17][CH2:18][CH2:19][C:13]=2[CH:12]=1.[Cl:28][S:29](O)(=[O:31])=[O:30].S(Cl)(Cl)=O>>[C:1]([N:17]1[CH2:16][CH:15]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:14]2[CH:26]=[C:27]([S:29]([Cl:28])(=[O:31])=[O:30])[C:11]([O:10][CH3:9])=[CH:12][C:13]=2[CH2:19][CH2:18]1)(=[O:8])[CH3:2]

Participants

4

Reactant 3

HCID 24386Thionyl ChlorideHCID 24638Chlorosulfonic acidHCID 68116039HCID 68116039, compound

Product 1

HCID 20160730HCID 20160730, compound

Procedure

Following the general procedure of Example 2, 7-methoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine maleate is acetylated and treated with chlorosulfonic acid followed by thionyl chloride to give 3-acetyl-8-chlorosulfonyl-7-methoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine.

Sources & evidence

ORD record
ord-168a6b9a0d66476e899945b02b80bbff
Source dataset
uspto-grants-1987_11
Patent number
US04707483

Reaction notes

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