Methylamine → Hydrochloric Acid

Participants

Reaction Steps

Following the general procedure of Example 2, 3-acetyl-8-chlorosulfonyl-7-methoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine is treated with methylamine and then with refluxing hydrochloric acid to afford 7-methoxy-8-(N-methylsulfamoyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride and the methoxy compound is treated with refluxing hydrobromic acid to give 7-hydroxy-8-(N-methylsulfamoyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide.

Provenance & Evidence