Methylamine → Hydrochloric Acid

HRID 247448Notes

Reaction equation

C([N:4]1[CH2:10][CH:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8]2[CH:17]=[C:18]([S:23]([Cl:26])(=[O:25])=[O:24])[C:19]([O:21][CH3:22])=[CH:20][C:7]=2[CH2:6][CH2:5]1)(=O)C.[CH3:27][NH2:28]>>[ClH:26].[ClH:26].[CH3:22][O:21][C:19]1[C:18]([S:23](=[O:24])(=[O:25])[NH:28][CH3:27])=[CH:17][C:8]2[CH:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH2:10][NH:4][CH2:5][CH2:6][C:7]=2[CH:20]=1

Participants

Reactant 2

HCID 6329Methylamine

HCID 20160730HCID 20160730, compound

Product 2

HCID 313Hydrochloric Acid

HCID 20160699HCID 20160699, compound

Procedure

Following the general procedure of Example 2, 3-acetyl-8-chlorosulfonyl-7-methoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine is treated with methylamine and then with refluxing hydrochloric acid to afford 7-methoxy-8-(N-methylsulfamoyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride and the methoxy compound is treated with refluxing hydrobromic acid to give 7-hydroxy-8-(N-methylsulfamoyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide.

Sources & evidence

ORD record: ord-e14436a1344b4f688737dfd6781cd897
Source dataset: uspto-grants-1987_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04707483

Reaction notes

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