Sodium Hydroxide → HCID 20160739, compound

HRID 247451Notes

Reaction equation

HRID 247451 reaction equation
[CH3:1][O:2][C:3]1[C:4]([S:26]([C:29]([F:32])([F:31])[F:30])(=[O:28])=[O:27])=[CH:5][C:6]2[CH2:12][CH2:11][N:10](C(=O)C(F)(F)F)[CH2:9][CH:8]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:7]=2[CH:25]=1.[OH-].[Na+]>CO>[CH3:1][O:2][C:3]1[C:4]([S:26]([C:29]([F:31])([F:30])[F:32])(=[O:28])=[O:27])=[CH:5][C:6]2[CH2:12][CH2:11][NH:10][CH2:9][CH:8]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)[C:7]=2[CH:25]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 20160710HCID 20160710, compound

Product 1

HCID 20160739HCID 20160739, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

8-Methoxy-1-phenyl-3-trifluoroacetyl-7-trifluoromethylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine (5 g, 0.01 m) dissolved in methanol is treated with 40% aqueous sodium hydroxide and stirred. The mixture is concentrated in vacuo and partitioned between ethyl acetate and water to give 8-methoxy-1-phenyl-7-trifluoromethylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine.

Workup

  1. concentrationThe mixture is concentrated in vacuo
  2. custompartitioned between ethyl acetate and water

Sources & evidence

ORD record
ord-91874b6c87344f10be9b496559a0d90a
Source dataset
uspto-grants-1987_11
Patent number
US04707483

Reaction notes

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