Potassium Cyanide → 2-(4-Bromo-3-methoxyphenyl)acetonitrile

HRID 247454Notes

Reaction equation

HRID 247454 reaction equation
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Cl)=[CH:4][C:3]=1[O:10][CH3:11].[C-:12]#[N:13].[K+]>C(O)C.O>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][C:12]#[N:13])=[CH:4][C:3]=1[O:10][CH3:11]

Participants

5

Reactant 2

HCID 9032Potassium CyanideHCID 20160668HCID 20160668, compound

Product 1

HCID 27355842-(4-Bromo-3-methoxyphenyl)acetonitrile

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

4-Bromo-3-methoxybenzyl chloride (23.5 g, 0.1 m) dissolved in ethanol (500 ml) is treated with potassium cyanide (13 g, 0.2 m) dissolved in water. The mixture is warmed and stirred to give 4-bromo-3-methoxyphenylacetonitrile.

Workup

  1. temperatureThe mixture is warmed

Sources & evidence

ORD record
ord-a321e99753494a428a047e7c4d9c680f
Source dataset
uspto-grants-1987_11
Patent number
US04707483

Reaction notes

Loading…