HCID 178450966, compound → HCID 178450965, compound

HRID 247543Notes

Reaction equation

HRID 247543 reaction equation
[CH2:1]([O:5][CH:6]([O:37][CH2:38][CH2:39][CH2:40][CH3:41])[CH:7]([CH2:30][CH2:31][CH2:32][NH:33][C:34](=[NH:36])[NH2:35])[NH:8][C:9](=[O:29])[CH2:10][NH:11][C:12](=[O:28])[C@@H:13]([CH:25]([CH3:27])[CH3:26])[NH:14]C(OCC1C=CC=CC=1)=O)[CH2:2][CH2:3][CH3:4]>CO.[Pd]>[CH2:38]([O:37][CH:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])[CH:7]([CH2:30][CH2:31][CH2:32][NH:33][C:34](=[NH:35])[NH2:36])[NH:8][C:9](=[O:29])[CH2:10][NH:11][C:12](=[O:28])[C@@H:13]([CH:25]([CH3:26])[CH3:27])[NH2:14])[CH2:39][CH2:40][CH3:41]

Participants

4

Reactant 1

HCID 178450966HCID 178450966, compound

Product 1

HCID 178450965HCID 178450965, compoundYield 136.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

132 mg of the N-benzyloxycarbonyl-D-valyl-glycyl-D,L-argininal dibutyl acetal was dissolved in 10 ml of methanol and subjected to catalytic reduction with palladium black for four hours. After the completion of the reaction, the palladium black was removed and the solvent was distilled off in vacuo to give 138 mg of D-valyl-glycyl-D,L-argininal dibutyl acetal in the form of a powder.

Workup

  1. customAfter the completion of the reaction
  2. customthe palladium black was removed
  3. distillationthe solvent was distilled off in vacuo

Sources & evidence

ORD record
ord-864692f12bcd4d56a1a34fed322eba3b
Source dataset
uspto-grants-1987_11
Patent number
US04708944

Reaction notes

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