反应详情

1 g of compound 1 and 3 g of pyridine hydrochloride were heated at 215° C. for 1 hour in a nitrogen atmosphere. After the mixture was cool,1.5 N hydrochloric acid was added thereto and then the supernatant was removed by centrifugation. The precipitate was dissolved in methanol which contains 10% of aqueous solution of sodium hydroxide, followed by filtering out the resulting precipitate. The obtained solution was acidified to give a crude product. The crude product was recrystallized from ethyl acetate to give 3-(p-hydroxybenzoyl)indole (compound 3). (Yield: 66%).

1. temperatureAfter the mixture was cool
2. customthe supernatant was removed by centrifugation
3. dissolutionThe precipitate was dissolved in methanol which
4. filtrationby filtering out the resulting precipitate
5. customto give a crude product
6. customThe crude product was recrystallized from ethyl acetate