MK-212 hydrochloride → 2-[4-[4-(6-Chloro-2-pyrazinyl)-1-piperazinyl]butyl]-5,6-dihydro-5-methyl-2H-1,2,6-thiadiazin-3(4H)-one 1,1 dioxide

HRID 247569노트

반응식

HRID 247569 반응식
Br[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:11](=[O:12])[CH2:10][CH:9]([CH3:13])[NH:8][S:7]1(=[O:15])=[O:14].Cl.[Cl:17][C:18]1[N:23]=[C:22]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:21]=[N:20][CH:19]=1>CN(C)C=O.C(N(CC)CC)C>[Cl:17][C:18]1[N:23]=[C:22]([N:24]2[CH2:25][CH2:26][N:27]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]3[C:11](=[O:12])[CH2:10][CH:9]([CH3:13])[NH:8][S:7]3(=[O:15])=[O:14])[CH2:28][CH2:29]2)[CH:21]=[N:20][CH:19]=1

참가 물질

5

반응물 2

HCID 198421MK-212 hydrochlorideHCID 139876582-(4-bromobutyl)-5,6-dihydro-5-methyl-2H-1,2,6-thiadiazin-3(4H)-one 1,1-dioxide

생성물 1

HCID 139876592-[4-[4-(6-Chloro-2-pyrazinyl)-1-piperazinyl]butyl]-5,6-dihydro-5-methyl-2H-1,2,6-thiadiazin-3(4H)-one 1,1 dioxide

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8471Triethylamine용매

실험 절차

The title compound is prepared by adding to a stirred solution of 2 g (0.006 mol) of 2-(4-bromobutyl)-5,6-dihydro-5-methyl-2H-1,2,6-thiadiazin-3(4H)-one 1,1-dioxide in 50 mL of dimethylformamide, 4 mL of triethylamine and 1.41 g (0.006 mol) of 1-(6-chloro-2-pyrazinyl)piperazine hydrochloride.

출처 및 근거

ORD 기록
ord-b4b0e66f29e0481091e0a145bd7ee22c
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04709027

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