HuagongsheHuagongshe Chemistry Print Report · For research reference only
MK-212 hydrochloride → 2-[4-[4-(6-Chloro-2-pyrazinyl)-1-piperazinyl]butyl]-5,6-dihydro-5-methyl-2H-1,2,6-thiadiazin-3(4H)-one 1,1 dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | MK-212 hydrochloride | HCID 198421 | — |
| Reactant | 2-(4-bromobutyl)-5,6-dihydro-5-methyl-2H-1,2,6-thiadiazin-3(4H)-one 1,1-dioxide | HCID 13987658 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 2-[4-[4-(6-Chloro-2-pyrazinyl)-1-piperazinyl]butyl]-5,6-dihydro-5-methyl-2H-1,2,6-thiadiazin-3(4H)-one 1,1 dioxide | HCID 13987659 | — |
Reaction Steps
The title compound is prepared by adding to a stirred solution of 2 g (0.006 mol) of 2-(4-bromobutyl)-5,6-dihydro-5-methyl-2H-1,2,6-thiadiazin-3(4H)-one 1,1-dioxide in 50 mL of dimethylformamide, 4 mL of triethylamine and 1.41 g (0.006 mol) of 1-(6-chloro-2-pyrazinyl)piperazine hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04709027 |
| Source dataset | uspto-grants-1987_11 |
| ORD ID | ord-b4b0e66f29e0481091e0a145bd7ee22c |
| Source note | uspto-grants-1987_11 |