Chloroform → HCID 20159910, compound

HRID 247580Notes

Reaction equation

HRID 247580 reaction equation
C([NH:4][CH:5]([CH3:21])[CH2:6][NH:7][S:8]([C:11]1[C:12]2[CH:13]=[CH:14][N:15]=[CH:16][C:17]=2[CH:18]=[CH:19][CH:20]=1)(=[O:10])=[O:9])(=O)C.C(Cl)(Cl)Cl>Cl>[NH2:4][CH:5]([CH3:21])[CH2:6][NH:7][S:8]([C:11]1[C:12]2[CH:13]=[CH:14][N:15]=[CH:16][C:17]=2[CH:18]=[CH:19][CH:20]=1)(=[O:10])=[O:9]

Participants

4

Reactant 2

HCID 6212ChloroformHCID 20159912HCID 20159912, compound

Product 1

HCID 20159910HCID 20159910, compoundYield 56%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

In 50 ml of 10% hydrochloride was dissolved 3.0 g of N-(2-acetylaminopropyl)-5-isoquinolinesulfonamide as obtained above, and the mixture was stirred at a temperature of 90° C. to 100° C. for 36 hours. The reaction solution was washed with chloroform, rendered alkaline with 1N sodium hydroxide and extracted with chloroform. The chloroform layer was washed with water, dried with anhydrous magnesium sulfate, and the chloroform was distilled threfrom under reduced pressure. The residue thus obtained was subjected to an alumina column chromatography (alumina: 70 g; solvent: chloroform) to give 1.44 g of N-(2-aminopropyl)-5-isoquinolinesulfonamide in a yield of 56%.

Workup

  1. customas obtained above, and the mixture
  2. washThe reaction solution was washed with chloroform
  3. extractionextracted with chloroform
  4. washThe chloroform layer was washed with water
  5. dry with materialdried with anhydrous magnesium sulfate
  6. distillationthe chloroform was distilled threfrom under reduced pressure
  7. customThe residue thus obtained

Sources & evidence

ORD record
ord-0360c2e73d7e4ea09c19a7f698f2feca
Source dataset
uspto-grants-1987_11
Patent number
US04709032

Reaction notes

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