5-Isoquinolinesulfonyl chloride → HCID 20159947, compound

HRID 247581Notes

Reaction equation

HRID 247581 reaction equation
[CH:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([S:11](Cl)(=[O:13])=[O:12])[C:5]=2[CH:4]=[CH:3][N:2]=1.[C:15]([O:19][C:20]([NH:22][CH2:23][CH:24]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[CH2:25][CH2:26][NH2:27])=[O:21])([CH3:18])([CH3:17])[CH3:16]>C(N(CC)CC)C>[C:15]([O:19][C:20]([NH:22][CH2:23][CH:24]([C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1)[CH2:25][CH2:26][NH:27][S:11]([C:6]1[C:5]2[CH:4]=[CH:3][N:2]=[CH:1][C:10]=2[CH:9]=[CH:8][CH:7]=1)(=[O:13])=[O:12])=[O:21])([CH3:18])([CH3:16])[CH3:17]

Participants

4

Reactant 2

HCID 33716555-Isoquinolinesulfonyl chlorideHCID 20159907HCID 20159907, compound

Product 1

HCID 20159947HCID 20159947, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The same procedure as described in Referential example 3 were repeated using 4.0 g of 5-isoquinolinesulfonyl chloride, 6.95 g of 4-t-butoxycarbonylamino-3-phenylbutylamine and 2.66 g of triethylamine, and there were obtained 6.6 g of N-(4-t-butoxycarbonylamino-3-phenylbutyl)-5-isoquinolinesulfonamide in a yield of 83%.

Sources & evidence

ORD record
ord-b326beaf934f47fd9f18e9316307aae1
Source dataset
uspto-grants-1987_11
Patent number
US04709032

Reaction notes

Loading…