Hydrochloric Acid → HCID 178478822, compound

HRID 247587Notes

Reaction equation

HRID 247587 reaction equation
[NH:1]([CH2:5][CH2:6][NH:7][S:8]([C:11]1[C:12]2[CH:13]=[CH:14][N:15]=[CH:16][C:17]=2[CH:18]=[CH:19][CH:20]=1)(=[O:10])=[O:9])[C:2]([NH2:4])=[NH:3].[ClH:21]>CO>[ClH:21].[ClH:21].[NH:1]([CH2:5][CH2:6][NH:7][S:8]([C:11]1[C:12]2[CH:13]=[CH:14][N:15]=[CH:16][C:17]=2[CH:18]=[CH:19][CH:20]=1)(=[O:10])=[O:9])[C:2]([NH2:4])=[NH:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178513008HCID 178513008, compound2×

Product 1

HCID 178478822HCID 178478822, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 20 ml of methanol was suspended 1.0 g of N-(2-guanidinoethyl)-5-isoquinolinesulfonamide, i.e., Compound (2), the crystalline residue was dissolved with 7.5 ml of 1N aqueous hydrochloride solution. The reaction mixture solution was condensed to dryness under reduced pressure, the crystalline residue thus obtained was recrystallized from methanol to give 1.12 g of N-(2-guanidinoethyl)-5-isoquinolinesulfonamide dihydrochloride in a yield of 90%.

Workup

  1. customcondensed to dryness under reduced pressure
  2. customthe crystalline residue thus obtained
  3. customwas recrystallized from methanol

Sources & evidence

ORD record
ord-635583be6c2a4fb5b63585f81ac9bf41
Source dataset
uspto-grants-1987_11
Patent number
US04709032

Reaction notes

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