反应详情

In 20 ml of methanol was suspended 1.0 g of N-(2-guanidinoethyl)-5-isoquinolinesulfonamide, i.e., Compound (2), the crystalline residue was dissolved with 7.5 ml of 1N aqueous hydrochloride solution. The reaction mixture solution was condensed to dryness under reduced pressure, the crystalline residue thus obtained was recrystallized from methanol to give 1.12 g of N-(2-guanidinoethyl)-5-isoquinolinesulfonamide dihydrochloride in a yield of 90%.

1. customcondensed to dryness under reduced pressure
2. customthe crystalline residue thus obtained
3. customwas recrystallized from methanol