Methyl iodide → HCID 178485730, compound

HRID 24765Notes

Reaction equation

HRID 24765 reaction equation
[F:1][C:2]([F:31])([F:30])[C:3]([NH:5][C:6]1[CH:7]=[C:8]([NH:12]/[C:13](=[C:20]2\[C:21](=[O:29])[NH:22][C:23]3[C:28]\2=[CH:27][CH:26]=[CH:25][CH:24]=3)/[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:9]=[CH:10][CH:11]=1)=[O:4].[C:32](=O)([O-])[O-].[K+].[K+].CI>CC(C)=O>[F:31][C:2]([F:1])([F:30])[C:3]([N:5]([C:6]1[CH:7]=[C:8]([NH:12]/[C:13](=[C:20]2\[C:21](=[O:29])[NH:22][C:23]3[C:28]\2=[CH:27][CH:26]=[CH:25][CH:24]=3)/[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:9]=[CH:10][CH:11]=1)[CH3:32])=[O:4]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 178517084HCID 178517084, compound

Product 1

HCID 178485730HCID 178485730, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

636 mg (1.5 mmol) of (Z)-3-[1-(3-trifluoroacetylamino-phenylamino)-1-phenyl-methylidene]-2-indolinone are dissolved in 20 ml of acetone and after the addition of 423 mg (3 mmol) of potassium carbonate and 0.25 g (3 mmol) of methyl iodide stirred for 18 hours at ambient temperature. The reaction solution is freed from the solvent in vacuo after the insoluble matter has been filtered off. The residue is divided between dichloromethane/water, the organic phase is dried and concentrated by evaporation. The residue is triturated with ether, suction filtered and dried.

Workup

  1. filtrationhas been filtered off
  2. customthe organic phase is dried
  3. concentrationconcentrated by evaporation
  4. customThe residue is triturated with ether, suction
  5. filtrationfiltered
  6. customdried

Sources & evidence

ORD record
ord-c964d2670dd14b5e8f9af9e39fb528a1
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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