HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 247701Generated: October 30, 2026
Acetic Acid → (-)-3-Hydroxybutyric acid phenylthioester
https://huagongshe.com/reaction/247701
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | (-)-3-t-Butyldimethylsilyloxybutyric acid phenylthioester | HCID 54408146 | — |
| Solvent | Water | HCID 962 | — |
| Product | (-)-3-Hydroxybutyric acid phenylthioester | HCID 53886232 | 94% |
Reaction Steps
There was added 50 ml of a mixture of acetic acid, THF and water (3:1:1) to 3.26 g (10.4 mml) of (-)-3-t-butyldimethylsilyloxybutyric acid phenylthioester and the mixture was stirred at 50° C. for 24 hours. The obtained reaction mixture was concentrated and distilled at 128° to 130° C. under a pressure of 0.8 mmHg to give 1.91 g of (-)-3-hydroxybutyric acid phenylthioester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04709064 |
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| Source dataset | uspto-grants-1987_11 |
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| ORD ID | ord-a8cb2faf215f46e2812383ae3605d68c |
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| Source note | uspto-grants-1987_11 |
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