Morpholine → 2-Morpholin-4-yl-N-(4-nitro-phenyl)-acetamide

HRID 24771Notes

Reaction equation

HRID 24771 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:14][C:15]([NH:17][C:18]1[CH:23]=[CH:22][C:21]([N+:24]([O-:26])=[O:25])=[CH:20][CH:19]=1)=[O:16]>CC(C)=O>[O:4]1[CH2:5][CH2:6][N:1]([CH2:14][C:15]([NH:17][C:18]2[CH:19]=[CH:20][C:21]([N+:24]([O-:26])=[O:25])=[CH:22][CH:23]=2)=[O:16])[CH2:2][CH2:3]1

Participants

5

Reactant 3

HCID 8083MorpholineHCID 11430Potassium CarbonateHCID 586678HCID 586678, compound

Product 1

HCID 28374662-Morpholin-4-yl-N-(4-nitro-phenyl)-acetamide

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

2.6 g (30 mmol) of morpholine and 4.2 g (30 mmol) of potassium carbonate are suspended in 120 ml of acetone. 5.3 g (20 mmol) of N-bromoacetyl-4-nitro-aniline, dissolved in 80 ml of acetone, are added dropwise over a period of 20 minutes and then stirred for 2 hours at ambient temperature. The precipitate is filtered off and the solvent is eliminated in vacuo. The residue is suspended with water. The precipitate is suction filtered and dried in a drying cupboard.

Workup

  1. additionare added dropwise over a period of 20 minutes
  2. filtrationThe precipitate is filtered off
  3. filtrationfiltered
  4. customdried in a drying cupboard

Sources & evidence

ORD record
ord-2c591e897c4e4ec2a42e2db7db901e48
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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