Ethyl isocyanate → HCID 178465296, compound

HRID 24772Notes

Reaction equation

HRID 24772 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8]/[C:9](=[C:16]2\[C:17](=[O:25])[NH:18][C:19]3[C:24]\2=[CH:23][CH:22]=[CH:21][CH:20]=3)/[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.[CH2:26]([N:28]=[C:29]=[O:30])[CH3:27]>C1COCC1>[CH2:26]([NH:28][C:29]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8]/[C:9](=[C:16]2\[C:17](=[O:25])[NH:18][C:19]3[C:24]\2=[CH:23][CH:22]=[CH:21][CH:20]=3)/[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:4][CH:3]=1)=[O:30])[CH3:27]

Participants

4

Reactant 2

HCID 8022Ethyl isocyanateHCID 178507732HCID 178507732, compound

Product 1

HCID 178465296HCID 178465296, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

196 mg (0.6 mmol) of (Z)-3-[1-(4-aminophenylamino)-1-phenyl-methylidene]-2-indolinone are suspended in 10 ml of THF and after the addition of 70 mg (0.1 mmol) of ethyl isocyanate stirred for 140 hours at ambient temperature. The product precipitated is suction filtered, washed with ether and dried.

Workup

  1. customThe product precipitated
  2. filtrationfiltered
  3. washwashed with ether
  4. customdried

Sources & evidence

ORD record
ord-5c1fa584a8a54ea0b4fece0e5be94381
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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