Sodium Hydroxide → HCID 178464111, compound

HRID 24775Notes

Reaction equation

HRID 24775 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[C:13](OCC)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:5]1=[O:23])(=O)C.[CH2:24]([N:26]([CH2:29][C:30]([N:32]([C:34]1[CH:40]=[CH:39][C:37]([NH2:38])=[CH:36][CH:35]=1)[CH3:33])=[O:31])[CH2:27][CH3:28])[CH3:25].[OH-].[Na+]>CN(C=O)C.CO>[CH2:24]([N:26]([CH2:29][C:30]([N:32]([C:34]1[CH:40]=[CH:39][C:37]([NH:38]/[C:13](=[C:6]2\[C:5](=[O:23])[NH:4][C:12]3[C:7]\2=[CH:8][CH:9]=[CH:10][CH:11]=3)/[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[CH:36][CH:35]=1)[CH3:33])=[O:31])[CH2:27][CH3:28])[CH3:25]

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 22569478HCID 22569478, compoundHCID 542378881-Acetyl-3-(1-ethoxy-1-phenylmethylidene}-2-indolinone

Product 1

HCID 178464111HCID 178464111, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6228DimethylformamideSolvent

Procedure

Prepared analogously to Example 43 from 1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-2-indolinone and 4-(N-diethylaminomethylcarbonyl-N-methyl-amino)-aniline in DMF and subsequent treatment with sodium hydroxide solution in methanol.

Sources & evidence

ORD record
ord-dee98381f5da4a1b8979f65c40027ac0
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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