HRID24777

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

结构：CN(C(=O)CN1CCN(Cc2ccccc2)CC1)c1ccc(N)cc1

HCID22569533

未命名化合物

结构：CCOC(=C1C(=O)N(C(C)=O)c2ccccc21)c1ccccc1

HCID54237888

未命名化合物

PRODUCTS

生成物

$结构：CN(C(=O)CN1CCN(Cc2ccccc2)CC1)c1ccc(N/C(=C2\C(=O)Nc3ccccc32)c2ccccc2)cc1$

HCID178485769

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Prepared analogously to Example 43 from 1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-2-indolinone and 4-[N-(4-benzylpiperazinomethylcarbonyl)-N-methylamino]-aniline in DMF and subsequent treatment with sodium hydroxide solution in methanol.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3e12fbf57bf84322ba5aa6308801d045
来源数据集: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06855710B2
来源说明: uspto-grants-2005_02

反应 SMILES

C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[C:13](OCC)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:5]1=[O:23])(=O)C.[CH2:24]([N:31]1[CH2:36][CH2:35][N:34]([CH2:37][C:38]([N:40]([C:42]2[CH:48]=[CH:47][C:45]([NH2:46])=[CH:44][CH:43]=2)[CH3:41])=[O:39])[CH2:33][CH2:32]1)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.[OH-].[Na+]>CN(C=O)C.CO>[CH2:24]([N:31]1[CH2:32][CH2:33][N:34]([CH2:37][C:38]([N:40]([C:42]2[CH:43]=[CH:44][C:45]([NH:46]/[C:13](=[C:6]3\[C:5](=[O:23])[NH:4][C:12]4[C:7]\3=[CH:8][CH:9]=[CH:10][CH:11]=4)/[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)=[CH:47][CH:48]=2)[CH3:41])=[O:39])[CH2:35][CH2:36]1)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1