反应详情

14.1 g of 30% strength sodium methylate solution was added to 10.9 g (0.078 mol) of methyl 2-methylimidazole-4-carboxylate in 100 ml of dimethylformamide; the methanol which formed was removed completely. 38.1 g (0.15 mol) of 1-fluoro-2,4-dibromobenzene was added to the dimethylformamide solution remaining, and the mixture was refluxed for 2 hours. Water was then added, extraction carried out with ethyl acetate and the ethyl acetate phase was washed with water. After removal of the solvent from the organic phase, there was obtained a residue which crystallized on trituration with diisopropyl ether.

1. customwas removed completely
2. temperaturethe mixture was refluxed for 2 hours
3. extractionextraction
4. washthe ethyl acetate phase was washed with water
5. customAfter removal of the solvent from the organic phase
6. customthere was obtained a residue which
7. customcrystallized on trituration with diisopropyl ether