反应详情

To a solution of 2-hydroxy-6-carboxynaphthalene (2 g) and optically active 1,1,1-trifluoro-2-octyl alcohol (2.2 g) in ethylene chloride (50 ml) was added a few drops of conc. sulfuric acid, and the solution was refluxed under stirring for about two days. The solution obtained was poured in water in order to collect the organic layer. The layer was washed with aqueous sodium hydroxide solution and water, in this order, and dried over anhydrous magnesium sulfate. The solution was distilled to remove the solvent. The residue was purified by silica-gel column chromatography (developer : chloroform) to obtain the titled compound (1.2 g).

1. temperaturethe solution was refluxed
2. customThe solution obtained
3. customto collect the organic layer
4. washThe layer was washed with aqueous sodium hydroxide solution and water, in this order
5. dry with materialdried over anhydrous magnesium sulfate
6. distillationThe solution was distilled
7. customto remove the solvent
8. customThe residue was purified by silica-gel column chromatography (developer : chloroform)