1-Bromopentane → HCID 67638877, compound

HRID 247819Notes

Reaction equation

HRID 247819 reaction equation
[ClH:1].[OH:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH:10]2[CH2:15][O:16][C:17]2[CH:22]=[CH:21][C:20]3[O:23][CH2:24][O:25][C:19]=3[CH:18]=2)=[CH:5][CH:4]=1.Br[CH2:27][CH2:28][CH2:29][CH2:30][CH3:31].C([O-])([O-])=O.[K+].[K+]>C(O)C>[ClH:1].[CH2:24]1[O:23][C:20]2[CH:21]=[CH:22][C:17]([O:16][CH2:15][C@H:10]3[C@H:9]([C:6]4[CH:7]=[CH:8][C:3]([O:2][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])=[CH:4][CH:5]=4)[CH2:14][CH2:13][N:12]([CH2:5][CH2:4][CH2:3][CH2:8][CH3:7])[CH2:11]3)=[CH:18][C:19]=2[O:25]1

Participants

5

Reactant 3

HCID 80571-BromopentaneHCID 11430Potassium CarbonateHCID 67853206HCID 67853206, compound

Product 1

HCID 67638877HCID 67638877, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(+-)-trans-3-(3,4-methylenedioxyphenoxymethyl)-1-pentyl-4-(4-pentyloxyphenyl)piperidine hydrochloride was prepared by refluxing 4-(4-hydroxyphenyl)-3-(3,4-methylenedioxyphenoxymethyl)piperidine hydrochloride (0.35 g) with 1-bromopentane (1.8 ml) and K2CO3 (1 g) in abs. ethanol (25 ml) for 2 h. The rinse-up procedure described in example 1 gave the title compound. M.p. 148.2° C.

Sources & evidence

ORD record
ord-479be24233494df78d2bed43d23b0a97
Source dataset
uspto-grants-1993_05
Patent number
US05208232

Reaction notes

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