Potassium Carbonate → N-Methyl-N-{1-[4-(p-fluorophenoxy)butyl]-4-piperidyl}acetamide

HRID 247844Notes

Reaction equation

HRID 247844 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1.[CH3:14][N:15]([CH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)[C:16](=[O:18])[CH3:17].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:14][N:15]([CH:19]1[CH2:20][CH2:21][N:22]([CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]2[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=2)[CH2:23][CH2:24]1)[C:16](=[O:18])[CH3:17]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 71722951-(4-Bromobutoxy)-4-fluorobenzeneHCID 21468403N-Methyl-N-(piperidin-4-yl)acetamide

Product 1

HCID 19764643N-Methyl-N-{1-[4-(p-fluorophenoxy)butyl]-4-piperidyl}acetamide

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture containing 0.1 mole of the compound obtained in stage A, 0.1 mole of the compound obtained in stage C and 0.1 mole of potassium carbonate in 250 cm3 of acetone is heated to reflux.

Workup

  1. temperatureis heated to reflux

Sources & evidence

ORD record
ord-ce950473b2dd45178768349bf3c73ee9
Source dataset
uspto-grants-1993_05
Patent number
US05208243

Reaction notes

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