反应详情

温度

130 °C

Imidazole (6.81 g, 0.10 mol, 1.0 eq), triethyl orthoformate (66.5 mL, 0.40 mol, 4.0 eq) and para-toluenesulfonic acid (0.5 g) were combined and heated at 130° C. Ethanol was slowly distilled off. After the distillation of the ethanol ceased, the reaction was distilled using a floor pump (0.1 mm). Excess triethyl orthoformate distilled at 50° C. and then the product was distilled at 78°-84° C. to give the title compound (12.316 g, 72%). B. 2-Butyl-1H-imidazole

1. distillationEthanol was slowly distilled off
2. distillationAfter the distillation of the ethanol
3. distillationthe reaction was distilled
4. distillationExcess triethyl orthoformate distilled at 50° C.
5. distillationthe product was distilled at 78°-84° C.