反应详情

Ethyl-3-[β-(3-methoxy-4-hydroxyphenyl)ethenyl]-1H-pyrazole-5-carboxylate (0.49 g, 1.7 mmoles) is added to a solution of KOH (0.38 g, 6.8 mmoles) in 0 ml EtOH. The reaction is warmed to reflux overnight. After cooling to room temperature, the reaction is diluted to 200 ml with H2O, and acidified to pH=4 with HCl. A white precipitate forms, and it is collected by filtration. Drying in vacuum in the presence of P2O5 gives 0.3 g (68%) of the desired product, mp=270°-271° C. (dec).

1. temperatureThe reaction is warmed
2. temperatureto reflux overnight
3. filtrationA white precipitate forms, and it is collected by filtration
4. dry with materialDrying in vacuum in the presence of P2O5