反应详情

温度

140 °C

A mixture of 1.0 g of product from Example 4 and 9.42 ml of ethyl iodide is heated, in a sealed dark tube, at 140° C. for 20 hours. The cooled reaction mixture is concentrated in vacuo, the residue purified by column chromatography (silica gel:10% methyl alcohol/chloroform) and recrystallized from 5% chloroform/methyl alcohol to give 0.96 g of the desired product.

1. customThe cooled reaction mixture
2. concentrationis concentrated in vacuo
3. customthe residue purified by column chromatography (silica gel:10% methyl alcohol/chloroform)
4. customrecrystallized from 5% chloroform/methyl alcohol