Acetic Anhydride → n-[2-(pyridin-2-yl)ethyl]acetamide

HRID 247923Notes

Reaction equation

HRID 247923 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][N:5]=1.[C:10](OC(=O)C)(=[O:12])[CH3:11]>CN(C)C1C=CN=CC=1.N1C=CC=CC=1>[N:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[CH2:3][CH2:2][NH:1][C:10](=[O:12])[CH3:11]

Participants

5

Reactant 2

HCID 7918Acetic AnhydrideHCID 759192-Pyridineethanamine

Product 1

HCID 238301n-[2-(pyridin-2-yl)ethyl]acetamide

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 1049PyridineSolvent

Procedure

The title compound is prepared by the procedure of Example 12 using 25 g of 2-(2-aminoethyl)pyridine, 22.2 ml of acetic anhydride, 2.57 g of 4-dimethylaminopyridine and 100 ml of pyridine. The residue is purified by column chromatography (silica gel:20% methyl alcohol/ethyl acetate) to give 7.5 g of desired product as a yellow oil.

Workup

  1. customThe residue is purified by column chromatography (silica gel:20% methyl alcohol/ethyl acetate)

Sources & evidence

ORD record
ord-49a94c608b114fe082cb8b642511abdb
Source dataset
uspto-grants-1993_05
Patent number
US05208247

Reaction notes

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