反应详情

The title compound is prepared by the procedure of Example 12 using 50 g of 3-(aminomethyl)pyridine, 50.2 ml of acetic anhydride, 2.26 g of 4-dimethylaminopyridine and 150 ml of pyridine without heating at reflux. The residue is purified by column chromatography (silica gel:20% methyl alcohol/ethyl acetate) to give 31.8 g of the desired product as a yellow oil.

1. temperaturewithout heating
2. temperatureat reflux
3. customThe residue is purified by column chromatography (silica gel:20% methyl alcohol/ethyl acetate)