反应详情

A mixture of 25 g of N,N-diethylsalicylamide, 38.5 ml of 1-bromotetradecane, 22.35 g of potassium carbonate and 400 ml of 2-butanone is heated at reflux temperature for 16 hours. The reaction is cooled, filtered and concentrated in vacuo. The concentrate is dissolved in chloroform, dried and concentrated in vacuo. The residue is purified by column chromatography (silica gel:0-30% ethyl acetate/hexane) to give 42.5 g of the desired product as colorless crystals.

1. temperatureis heated
2. temperatureat reflux temperature for 16 hours
3. temperatureThe reaction is cooled
4. filtrationfiltered
5. concentrationconcentrated in vacuo
6. dissolutionThe concentrate is dissolved in chloroform
7. customdried
8. concentrationconcentrated in vacuo
9. customThe residue is purified by column chromatography (silica gel:0-30% ethyl acetate/hexane)