Methyl iodide → HCID 10008845, compound

HRID 247937Notes

Reaction equation

HRID 247937 reaction equation
[C:1]([N:4]([CH2:28][C:29]1[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=1)[C:5](=[O:27])[C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[CH:8][CH:7]=1)(=[O:3])[CH3:2].[CH3:35][I:36]>>[I-:36].[C:1]([N:4]([CH2:28][C:29]1[CH:30]=[N+:31]([CH3:35])[CH:32]=[CH:33][CH:34]=1)[C:5](=[O:27])[C:6]1[CH:7]=[CH:8][C:9]([O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[CH:10][CH:11]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 10434714HCID 10434714, compound

Product 1

HCID 10008845HCID 10008845, compound

Conditions

Temperature
110 °C

Procedure

A mixture of 0.281 g of product from Example 27 and 1.88 ml of methyl iodide is heated in a sealed tube at 110° C. for 20 hours. The cooled solution is concentrated in vacuo and the residue recrystallized from methyl alcohol to give 0.367 g of the desired product as cream crystals.

Workup

  1. concentrationThe cooled solution is concentrated in vacuo
  2. customthe residue recrystallized from methyl alcohol

Sources & evidence

ORD record
ord-5c3eb44083e14daa8978b2145522b206
Source dataset
uspto-grants-1993_05
Patent number
US05208247

Reaction notes

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