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Sodium hydride → N-Acetyl-N-(2-pyridinylmethyl)-3-(tetradecyloxy)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | N-(pyridin-2-ylmethyl)acetamide | HCID 5084090 | — |
| 反応物 | 3-(Tetradecyloxy)benzoyl chloride | HCID 19014949 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-Acetyl-N-(2-pyridinylmethyl)-3-(tetradecyloxy)benzamide | HCID 10367289 | — |
反応手順
The title compound prepared by the procedure of Example 27 using 0.462 g of product from Example 12 in 4 ml of dry tetrahydrofuran, 0.147 g of washed 50% sodium hydride and 1.03 g of product from Example 26 in 4 ml of dry tetrahydrofuran. The residue is purified by column chromatography (silica gel: 35% ethyl acetate/hexane) to give 0.178 g of the desired product as a yellow oil which crystallized on standing.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05208247 |
| 出典データセット | uspto-grants-1993_05 |
| ORD ID | ord-7401f59bd8ce4787af51cf3b7d5f00bd |
| 出典メモ | uspto-grants-1993_05 |