Sodium hydride → N-Acetyl-N-(2-pyridinylmethyl)-3-(tetradecyloxy)benzamide

HRID 247938ノート

反応式

HRID 247938 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][NH:8][C:9](=[O:11])[CH3:10].[H-].[Na+].[CH2:14]([O:28][C:29]1[CH:30]=[C:31]([CH:35]=[CH:36][CH:37]=1)[C:32](Cl)=[O:33])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27]>O1CCCC1>[C:9]([N:8]([CH2:7][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)[C:32](=[O:33])[C:31]1[CH:35]=[CH:36][CH:37]=[C:29]([O:28][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH:30]=1)(=[O:11])[CH3:10]

参加物

5

反応物 3

HCID 24758Sodium hydrideHCID 5084090N-(pyridin-2-ylmethyl)acetamideHCID 190149493-(Tetradecyloxy)benzoyl chloride

生成物 1

HCID 10367289N-Acetyl-N-(2-pyridinylmethyl)-3-(tetradecyloxy)benzamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

The title compound prepared by the procedure of Example 27 using 0.462 g of product from Example 12 in 4 ml of dry tetrahydrofuran, 0.147 g of washed 50% sodium hydride and 1.03 g of product from Example 26 in 4 ml of dry tetrahydrofuran. The residue is purified by column chromatography (silica gel: 35% ethyl acetate/hexane) to give 0.178 g of the desired product as a yellow oil which crystallized on standing.

出典と根拠

ORDレコード
ord-7401f59bd8ce4787af51cf3b7d5f00bd
出典データセット
uspto-grants-1993_05
特許番号
US05208247

反応ノート

読み込み中…