HRID247943

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24758

Sodium hydride

HNa

HCID5084090

N-(pyridin-2-ylmethyl)acetamide

C8H10N2O

结构：CCCCCCCCCCCCCCOc1ccc(C(=O)Cl)cc1C(C)(C)C

HCID19015370

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2ccccn2)C(C)=O)cc1C(C)(C)C

HCID10075454

未命名化合物

收率 51.9%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

The title compound is prepared by the procedure of Example 27 using 9.7 g of product from Example 33, 3.74 g of product from Example 12, 1.2 g of washed 50% sodium hydride and 100 ml of tetrahydrofuran. The residue is purified by column chromatography (silica gel:30% ethyl acetate/hexane) to give 6.43 g of the desired product as colorless crystals.

WORKUP

后处理

customThe residue is purified by column chromatography (silica gel:30% ethyl acetate/hexane)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-55c55e20f6324afbae434179e6f72aae
来源数据集: uspto-grants-1993_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05208247
来源说明: uspto-grants-1993_05

反应 SMILES

[CH3:1][C:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[C:8](Cl)=[O:9])([CH3:4])[CH3:3].[N:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[CH2:35][NH:36][C:37](=[O:39])[CH3:38].[H-].[Na+]>O1CCCC1>[C:37]([N:36]([CH2:35][C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][N:29]=1)[C:8](=[O:9])[C:7]1[CH:11]=[CH:12][C:13]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[C:5]([C:2]([CH3:4])([CH3:3])[CH3:1])[CH:6]=1)(=[O:39])[CH3:38]