HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → N-Acetyl-3-(1,1-Dimethylethyl)-4-(tetradecyloxy)-N-(2-pyridinylmethyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | N-(pyridin-2-ylmethyl)acetamide | HCID 5084090 | — |
| Reactant | 3-(1,1-Dimethylethyl)-4-(tetradecyloxy)benzoyl chloride | HCID 19015370 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-Acetyl-3-(1,1-Dimethylethyl)-4-(tetradecyloxy)-N-(2-pyridinylmethyl)benzamide | HCID 10075454 | 51.9% |
Reaction Steps
The title compound is prepared by the procedure of Example 27 using 9.7 g of product from Example 33, 3.74 g of product from Example 12, 1.2 g of washed 50% sodium hydride and 100 ml of tetrahydrofuran. The residue is purified by column chromatography (silica gel:30% ethyl acetate/hexane) to give 6.43 g of the desired product as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05208247 |
| Source dataset | uspto-grants-1993_05 |
| ORD ID | ord-55c55e20f6324afbae434179e6f72aae |
| Source note | uspto-grants-1993_05 |