Ethanol → HCID 13354737, compound

HRID 247956Notes

Reaction equation

HRID 247956 reaction equation
C[O:2][C:3](=[O:27])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])=[C:6]([O:25][CH3:26])[CH:5]=1.CO.C(O)C.[OH-].[K+]>O>[CH3:26][O:25][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[C:3]([OH:27])=[O:2]

Participants

6

Reactant 4

HCID 702EthanolHCID 887MethanolHCID 14797Potassium HydroxideHCID 54425506HCID 54425506, compound

Product 1

HCID 13354737HCID 13354737, compoundYield 83.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title compound is prepared by the procedure of Example 32 using 40 g of the product from Example 46, 320 ml of methyl alcohol, 125 ml ethyl alcohol, 20 ml of water and 17.8 g of potassium hydroxide. The residue is recrystallized from chloroform/hexane to give 32 g of the desired product as white crystals.

Workup

  1. customThe residue is recrystallized from chloroform/hexane

Sources & evidence

ORD record
ord-c80d21e788f6413898e7a7b9c4dde8a9
Source dataset
uspto-grants-1993_05
Patent number
US05208247

Reaction notes

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