Methyl iodide → 1-Methyl-2-[[[[4-(tetradecyloxy)phenyl]acetyl]amino]methyl]pyridinium iodide

HRID 247964Notes

Reaction equation

HRID 247964 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][NH:8][C:9](=[O:32])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])=[CH:13][CH:12]=1.[CH3:33][I:34]>>[I-:34].[CH3:33][N+:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][NH:8][C:9](=[O:32])[CH2:10][C:11]1[CH:12]=[CH:13][C:14]([O:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 10365880N-(2-Pyridinylmethyl)-4-(tetradecyloxy)benzeneacetamide

Product 1

HCID 100311351-Methyl-2-[[[[4-(tetradecyloxy)phenyl]acetyl]amino]methyl]pyridinium iodideYield 87.6%

Procedure

The title compound is prepared by the procedure of Example 28 using 1.0 g of product from Example 54 and 16.18 g of methyl iodide. The residue is recrystallized from methyl alcohol to give 1.16 g of the desired product as cream prisms.

Workup

  1. customThe residue is recrystallized from methyl alcohol

Sources & evidence

ORD record
ord-d9a1a85cd6214c4d87c938ed980896e4
Source dataset
uspto-grants-1993_05
Patent number
US05208247

Reaction notes

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