反应详情

A solution of 24.5 g of product from Example 85, 10.14 g of potassium hydroxide, 10 ml of water and 250 ml of ethyl alcohol is heated at reflux for 3 hours; followed by standing at 50° C. for 18 hours. The reaction is poured into dilute hydrochloric acid, extracted with chloroform, dried and concentrated. The residue is recrystallized from hexane/carbon tetrachloride to give 13.7 g of the desired product as a white solid.

1. temperatureat reflux for 3 hours
2. extractionextracted with chloroform
3. customdried
4. concentrationconcentrated
5. customThe residue is recrystallized from hexane/carbon tetrachloride