HRID248005

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6328

Methyl iodide

CH3I

结构：CCCCCCCCCCCCCCOc1ccc(COC(=O)N(Cc2ccccn2)C(C)=O)cc1

HCID9983311

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCOc1ccc(COC(=O)N(Cc2cccc[n+]2C)C(C)=O)cc1.[I-]

HCID10349150

未命名化合物

收率 93.7%

CONDITIONS

反应条件

温度: 100 °C

PROCEDURE

实验过程

A mixture of 1.37 g of product from Example 96 and 19.55 g of methyl iodide is heated in a sealed tube at 100° C. for 5 hours. The reaction is concentrated in vacuo and the residue recrystallized from methyl alcohol to give 1.65 g of the desired product.

WORKUP

后处理

concentrationThe reaction is concentrated in vacuo
customthe residue recrystallized from methyl alcohol

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-038f003302c643be86b1536f6955fe6d
来源数据集: uspto-grants-1993_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05208247
来源说明: uspto-grants-1993_05

反应 SMILES

[C:1]([N:4]([CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][N:32]=1)[C:5](=[O:29])[O:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[CH:10][CH:9]=1)(=[O:3])[CH3:2].[CH3:37][I:38]>>[I-:38].[C:1]([N:4]([CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][N+:32]=1[CH3:37])[C:5]([O:6][CH2:7][C:8]1[CH:9]=[CH:10][C:11]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[CH:12][CH:13]=1)=[O:29])(=[O:3])[CH3:2]