反应详情

A mixture of 25 g of product from Example 102, 72.3 g of 1-iodoheptane, 61.65 g of potassium carbonate and 500 ml of 2-butanone is heated at reflux temperature for 44 hours. The cooled reaction mixture is filtered and concentrated in vacuo. The oily residue is purified by chromatography (silica gel: 10% ethyl acetate/hexane) to give 53.7 g of the desired product.

1. temperatureis heated
2. temperatureat reflux temperature for 44 hours
3. customThe cooled reaction mixture
4. filtrationis filtered
5. concentrationconcentrated in vacuo
6. customThe oily residue is purified by chromatography (silica gel: 10% ethyl acetate/hexane)